Custom Protein Service

Special proteins, including difficult-to-express, low-stability, highly hydrophobic or biologically toxic proteins, pose high preparation difficulty and low success rates in academic research and drug development. We offer professional custom services for special proteins. Based on the intrinsic properties and intended applications of target proteins, we design scientific and feasible comprehensive solutions. With multiple mature expression systems, we leverage sequence optimization, rational tag design and fine-tuned expression parameters to improve protein yield and stability. Custom purification workflows retain native structure and bioactivity. Strict QC testing on all final samples ensures high purity, consistent batches and repeatable results to back up complex R&D projects.

  • >90%

    High Success Rate for Protein Delivery

  • Over 1000 projects completed

    Rich experience in difficult-to-express proteins

  • Bioactivity retention ≥90%

    High retention of protein bioactivity

  • 10+ types of tags /modifications

    Customizable tags and modifications

  • μg–g

    Flexible delivery with multiple specifications

General Service Workflow

  • Demand Assessment

  • Solution Design

  • System Screening

  • Expression Optimization

  • Purification & Preparation

  • Quality Testing

  • Result Delivery

Expression Systems

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Technical Capabilities
Application Fields
Quality Standards
Service Advantages
 

Multi-pass Transmembrane Protein Development

Supports proteins with more than 6 transmembrane domains

• GPCR / Ion Channel Research • Functional Analysis of Multi-transmembrane Structures • Membrane Protein Drug Screening

• Conformational Integrity Verification • Detectable Functional Activity • Passed Stability Assessment

• High Success Rate for Challenging Membrane Proteins • Parallel Optimization of Multiple Expression Systems • Markedly Shortened Development Cycle

Protein Labeling Quantification

Labeling ratio deviation ≤ 10%

・SPR/BLI quantitative analysis ・MST & fluorescence detection ・Protein-protein interaction verification

・Controllable labeling ratio ・Batch-to-batch deviation ≤ 10% ・High signal reproducibility

・Stable and reliable quantitative results ・Excellent batch consistency ・Compatible with multiple detection platforms

Endotoxin Removal Services

Controllable endotoxin content <0.1 EU/μg

• Cellular functional assays • In vivo animal studies • Pharmacodynamic and safety evaluation

• Endotoxin level < 0.1 EU/μg • High protein recovery rate • Excellent retention of biological activity

• Thorough endotoxin clearance without impairing protein activity • Compatible with cellular and in vivo studies • Fast turnaround with short processing cycle

Custom Protein Tagging Services

10+ tag combinations available

• Affinity Purification • WB & ELISA Detection • Imaging & Localization Analysis

• Stable tag fusion • No interference with protein function • Verifiable purification efficiency

• Flexible selection of tag types • Improved purification and detection efficiency • Compatible with multiple experimental applications

More related services

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Frequently Asked Questions

  • What kinds of proteins are generally defined as "special proteins"?

    Special proteins feature tough technical challenges in expression, purification or stability: multi-transmembrane, highly hydrophobic, low-expression, degradable proteins, proteins with complex domains/PTMs, and host-toxic proteins incompatible with regular systems. Customized schemes are necessary instead of generic standard protocols.

  • What are the main differences between custom special protein services and standard protein expression services?

    Custom special protein services focus more on preliminary assessment and strategy planning than routine protein services. We systematically analyze protein sequences, structural traits and experimental demands before project launch, and prepare primary and backup schemes to reduce repeated trials, lifting project success rate and turnaround efficiency.

  • Is it possible to express only the functional domains or transmembrane fragments of a protein?

    Yes. Full-length proteins, functional fragments or transmembrane segments can be customized according to your experimental objectives. Fragmentation design usually improves expression success rate, protein stability and the operability of downstream experiments, and is especially suitable for functional research and protein interaction analysis.

  • How to guarantee the conformational integrity and biological activity of special proteins?

    We preserve the native conformation and functional activity of proteins to the maximum extent by rationally selecting expression systems, optimizing induction parameters, adopting mild purification workflows and designing stabilizing buffer formulations. When necessary, we can provide activity assay or functional verification data as quality references.

If you have any questions, please contact us.

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IPODIX Biotech Inc

2108 N ST, STE N
Sacramento, CA 95816, USA

For Product Information and Orders

sales@ipodix.com

For Business Collaboration

sales@ipodix.com

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sales@ipodix.com

For Technical Support

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  • 50000+

    Recombinant Proteins

  • 100+

    Researchers

  • 100+

    Countries Served

  • ISO

    Certified Quality

Committed to Quality
Driven by Innovation

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