Analytical Data
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Gene name
KBTBD6
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简介
KBTBD6 is a key member of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, acting as a substrate adapter to coordinate the “Lys-48” ubiquitination and subsequent proteasomal degradation of the RAC1 guanine exchange factor TIAM1. This regulatory role enables KBTBD6 to control RAC1 signaling, affecting important processes such as cytoskeletal organization, cell migration, and cell proliferation. KBTBD6 Protein, Human (sf9) is the recombinant human-derived KBTBD6 protein, expressed by sf9 insect cells , with tag free.
- Application
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Alternative Names
KBTBD6; Kelch repeat and BTB domain-containing protein 6
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Species
Human
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Source
Baculovirus
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86V97
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Expression Region
Q2-Q674
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KBTBD6 is a member of the Kelch repeat and BTB (BR-C, TTC, and C-terminal) domain-containing protein family, which plays significant roles in various cellular processes including protein degradation and signal transduction. Recent research has highlighted the importance of KBTBD6 in regulating cellular functions through its involvement in the ubiquitin-proteasome pathway, where it acts as an E3 ubiquitin ligase. Dysregulation of KBTBD6 has been associated with several diseases, including cancer and neurodegenerative disorders, making it an attractive target for therapeutic intervention. The study of KBTBD6 recombinant proteins allows for a deeper understanding of its structure-function relationship and interactions with other cellular components, facilitating the elucidation of its role in disease mechanisms. Additionally, the exploration of KBTBD6 may provide insights into novel drug development strategies aimed at modulating its activity for therapeutic benefits. Overall, the investigation of KBTBD6 recombinant proteins is crucial for advancing our knowledge of cellular regulation and its implications for health and disease.
