Analytical Data
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Gene name
RGS4
- Application
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Alternative Names
RGP4; SCZD9; Schizophrenia Disorder 9
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49798
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Expression Region
Ser38~Ala205
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Molecular Weight
23kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RGS4, or Regulator of G-protein Signaling 4, is a member of the RGS protein family, which plays a crucial role in modulating G-protein-coupled receptor (GPCR) signaling pathways. GPCRs are involved in numerous physiological processes, making RGS proteins significant in the regulation of cellular responses to various stimuli. Research has shown that RGS4 negatively regulates G-protein signaling by accelerating the GTPase activity of Gα subunits, thereby promoting the transition from the active GTP-bound state back to the inactive GDP-bound state. Abnormal expression or function of RGS4 has been linked to various diseases, including psychiatric disorders, cardiovascular diseases, and cancer, highlighting its potential as a therapeutic target. The study of recombinant RGS4 protein has gained attention in both basic and applied research to elucidate its mechanisms in cell signaling and to explore its role in health and disease. Characterizing this protein through recombinant technology allows for detailed functional analyses, interaction studies with GPCRs, and the development of small-molecule modulators. Furthermore, understanding RGS4's structure-function relationship can illuminate the intricacies of G-protein signaling pathways and its implications in drug discovery. As a result, RGS4 recombinant protein research is pivotal in advancing our knowledge of cellular signaling and its impact on human health.
