Analytical Data
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Gene name
BLOC1S2
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简介
BLOC1S2 is an essential component of the BLOC-1 complex and is critical for the biogenesis of lysosome-related organelles (LROs), including platelet dense granules and melanosomes. BLOC-1 cooperates with the AP-3 complex to direct membrane protein cargo into vesicles for delivery to neurites and nerve terminals, suggesting that it is involved in neurite extension. BLOC1S2 Protein, Human (N-GST) is the recombinant human-derived BLOC1S2 protein, expressed by E. coli , with N-GST labeled tag.
- Application
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Alternative Names
Biogenesis of lysosome-related organelles complex 1 subunit 2; BLOC-1 subunit 2; BLOS2; CEAP
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Species
Human
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Source
E. coli
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Tag
N-GST
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q6QNY1-2
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Expression Region
M1-R99
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Protein Length
Full Length of Isoform-2
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Molecular Weight
34 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BLOC1S2, a component of the Biogenesis of Lysosome-related Organelles Complex-1 (BLOC-1), plays a crucial role in intracellular trafficking and the formation of lysosome-related organelles. Research into BLOC1S2 has gained significant attention due to its implications in various cellular processes, including endocytosis, autophagy, and the biogenesis of melanosomes, which are vital for pigmentation in skin and hair. Mutations and dysregulation of BLOC1S2 have been linked to certain genetic disorders, such as Hermansky-Pudlak Syndrome, characterized by oculocutaneous albinism and bleeding diathesis. Understanding the structure and function of BLOC1S2 is essential for unraveling the molecular mechanisms underlying these conditions. Furthermore, the study of BLOC1S2 may provide insights into broader aspects of organelle dysfunction and cellular homeostasis. Recent advances in cryo-electron microscopy and molecular biology techniques have enabled researchers to explore the protein's interactions and its role within the BLOC-1 complex, highlighting potential therapeutic targets for related disorders. As a result, BLOC1S2 is positioned at the intersection of cell biology, genetics, and therapeutic research, marking it as a focal point for future investigations aimed at improving our understanding of lysosomal diseases and developing novel therapeutic strategies.
