Analytical Data
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Gene name
BANF1
- Application
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Alternative Names
BAF; BCRP1; Breakpoint cluster region protein 1; Barrier-to-autointegration factor, N-terminally processed
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75531
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Expression Region
Thr2~Leu89
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Molecular Weight
14kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BANF1 (Barrier-to-Autointegration Factor 1) is a nuclear protein that plays a critical role in maintaining genome integrity, chromatin organization, and cellular responses to DNA damage. Its function is particularly relevant in the context of viral infections and cancer, where it is implicated in the regulation of nuclear architecture and the expression of specific genes. Research has shown that BANF1 is involved in mediating the integration of viral genomes into the host's DNA, which is essential for the life cycle of various viruses, including lentiviruses. Moreover, its ability to interact with chromatin and other nuclear proteins suggests that BANF1 plays a significant role in the dynamic processes of DNA repair and replication. Given its multifaceted role in cellular processes, BANF1 has emerged as a potential target for therapeutic interventions in diseases characterized by genomic instability, such as cancer. Studies have focused on understanding the structural and functional properties of BANF1, leading to the expression and purification of recombinant BANF1 proteins. These recombinant proteins are crucial for elucidating BANF1's mechanisms of action and for exploring its potential applications in biotechnology and medicine, including gene therapy and antiviral strategies. Understanding the functional dynamics of BANF1 could provide insights into the development of novel therapeutic approaches that enhance genome stability or disrupt viral integration processes. Therefore, the study of BANF1 is essential for advancing our knowledge of nuclear biology, and it holds promise for future biomedical applications.
