Analytical Data
-
基因名
Integrin alpha 5 beta 1
-
简介
ITGA5 is a multifunctional receptor that interacts with multiple ligands such as fibronectin, fibrinogen, PLA2G2A, fibrillin-1 (FBN1), IL1B, human metapneumovirus, and soluble CD40LG. ITGA5 recognizes RGD sequences and mediates cell adhesion through different binding sites. Integrin alpha 5 beta 1 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha 5 beta 1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. Integrin alpha 5 beta 1 Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 110-140 kDa.
- Application
-
别名
Integrin alpha 5 beta 1; VLA-5; ITGA5&ITGB1; Integrin alpha 5 β 1; α5β1
-
种属
Human
-
表达系统
HEK293
-
标签
C-Avi;C-8*His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P08648 (F42-Y995)&P05556
-
表达区间
P08648 (F42-Y995)&P05556 (Q21-D728)
-
分子量
110-140 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Integrin alpha 5 beta 1 is a vital member of the integrin family, functioning as a cell surface receptor that mediates cell-extracellular matrix (ECM) interactions, particularly by binding to fibronectin. This receptor plays a critical role in various biological processes, including cell adhesion, migration, differentiation, and tissue development. Research has shown that integrin alpha 5 beta 1 is involved in several pathological conditions, such as cancer metastasis, fibrosis, and wound healing. The dysregulation of this integrin can lead to impaired cellular functions and contribute to disease progression. Consequently, recombinant integrin alpha 5 beta 1 has garnered significant interest as both a research tool and a potential therapeutic target. The ability to produce this protein in a recombinant form allows for detailed structural and functional studies, facilitating a deeper understanding of its role in various cellular processes. Additionally, it opens up avenues for the development of integrin-based therapies, including the design of integrin antagonists that could inhibit tumor progression or enhance tissue regeneration. Understanding the precise mechanisms by which integrin alpha 5 beta 1 operates will not only shed light on fundamental biological processes but also contribute to the advancement of targeted therapies in regenerative medicine and oncology. Researchers are focusing on characterizing this integrin's interactions and signaling pathways, emphasizing its potential as a biomarker for disease prognosis and a target for innovative treatment strategies.
