Analytical Data
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基因名
HMGN1
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简介
The HMGN1 protein is a key player in the immune response, binding to the Fc region of immunoglobulin alpha and specifically promoting the production of cytokines. HMGN1 is intricately related to the Fc epsilon RI gamma 2 receptor, can induce tyrosine phosphorylation of gamma 2, and actively participates in the complex coordination of immune signaling pathways. HMGN1 Protein, Human is the recombinant human-derived HMGN1 protein, expressed by E. coli , with tag free.
- Application
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生物活性
Measured by its binding ability in a functional ELISA. Immobilized HMGN1 at 2 μg/mL (100 μL/well) can bind anti- HMGN1 Antibody. The ED50 for this effect is 57.03 ng/mL. Measured by its binding ability in a functional ELISA. Immobilized HMGN1 at 2 μg/mL (100 μL/well) can bind anti-HMGN1 Antibody. The ED50 for this effect is 57.03 ng/mL.
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别名
Non-histone chromosomal protein HMG-14; HMGN1; High mobility group nucleosome-binding domain-containing protein 1; HMG14; High Mobility Group Nucleosome Binding Domain 1
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P05114
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表达区间
P2-D100
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分子量
19 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HMGN1, a member of the high mobility group (HMG) protein family, plays a crucial role in modulating chromatin structure and function. This non-histone protein interacts with nucleosomes, influencing gene expression, DNA repair, and cellular response to stress. Recent studies have highlighted its significance in various biological processes and its potential involvement in cancer progression, inflammation, and immune responses. Due to its pivotal function in chromatin dynamics, HMGN1 has attracted considerable attention for its potential as a therapeutic target and biomarker in several diseases. Researchers have been focusing on the production of recombinant HMGN1 protein to better understand its biochemical properties and physiological roles. Advances in recombinant DNA technology allow for the efficient expression and purification of HMGN1, enabling detailed studies of its interactions with DNA and other nuclear proteins. Investigating the structural and functional characteristics of HMGN1 can provide insights into its mechanisms of action and its potential implications in both health and disease. Understanding HMGN1's role may lead to novel strategies for therapeutic intervention, particularly in cancer and other disorders linked to chromatin remodeling. Thus, the study of recombinant HMGN1 is pivotal for elucidating its biological functions and therapeutic potential.
