Analytical Data
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Gene name
Thioredoxin/TRX
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简介
Thioredoxin/TRX proteins participate in multiple redox reactions, utilizing their reactive dithiol centers for reversible oxidation and disulfide bond formation.It catalyzes important dithiol-disulfide exchange and plays a key role in S-nitrosylation of cysteine residues in response to intracellular nitric oxide.Thioredoxin/TRX Protein, Mouse is the recombinant mouse-derived Thioredoxin/TRX protein, expressed by E.coli , with tag free.
- Application
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Alternative Names
Thioredoxin; TXN; Trx; ADF; TRX1; SASP
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Species
Mouse
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P10639
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Expression Region
M1-A105
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Protein Length
Full Length
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Molecular Weight
15 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Thioredoxin (TRX) is a small redox-active protein that plays a crucial role in various biological processes, including cell proliferation, apoptosis, and the response to oxidative stress. It serves as a key component of the cellular antioxidant defense system by maintaining the redox state of other proteins and enzymes through its reducing activity, which is primarily facilitated by a pair of conserved cysteine residues in its active site. The significance of TRX in cellular metabolism and its involvement in numerous pathological conditions, such as cancer and neurodegenerative diseases, have spurred extensive research into its properties and applications. Recombinant TRX proteins have become valuable tools in biotechnology and biomedicine, as they can be utilized to enhance protein solubility, stability, and activity during the purification process. Additionally, TRX can serve as a carrier for the delivery of peptides and proteins, providing a platform for the development of therapeutic agents. The study of recombinant TRX has led to insights into its structure-function relationships, redox mechanisms, and potential as a therapeutic target. Given the increasing incidence of oxidative stress-related diseases, continued research into TRX and its recombinant forms holds promise for the development of novel therapeutic strategies.
