Analytical Data
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Gene name
REXO2
- Application
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Alternative Names
SFN; RFN; SMFN; Oligoribonuclease, mitochondrial; Small fragment nuclease
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y3B8
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Expression Region
Gln41~Asn213
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Molecular Weight
22kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
REXO2 is a critical member of the exoribonuclease family, primarily involved in RNA metabolism and degradation. Its role in cellular processes such as mRNA decay, ribosome biogenesis, and the regulation of gene expression has garnered significant attention in molecular biology research. This enzyme is particularly important in maintaining cellular RNA homeostasis by ensuring the timely degradation of unwanted or damaged RNA species, thus preventing the accumulation of potentially harmful RNA molecules. Dysregulation of REXO2 has been implicated in various diseases, including cancer, where altered RNA processing can contribute to malignant transformation and tumor progression. Additionally, understanding the mechanisms of REXO2 function may offer insights into broader RNA-related pathways and their implications in cellular health. Researchers have been focusing on the structural and functional characterization of REXO2, exploring its enzymatic activity, substrate specificity, and interactions with other molecular players in the RNA metabolic pathway. The recombinant expression of REXO2 protein has facilitated detailed biochemical assays and has opened avenues for potential therapeutic applications, harnessing this knowledge for interventions in diseases characterized by dysregulated RNA metabolism. Overall, the study of REXO2 is not only vital for basic science but also holds promise for translational research aimed at developing novel strategies for disease treatment and prevention.
