Analytical Data
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Gene name
G3BP2
- Application
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Alternative Names
G3BP2；KIAA0660;Ras GTPase-activating Protein-binding Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UN86
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Expression Region
1-449aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMVMEKP SPLLVGREFV RQYYTLLNKA PEYLHRFYGR NSSYVHGGVD ASGKPQEAVY GQNDIHHKVL SLNFSECHTK IRHVDAHATL SDGVVVQVMG LLSNSGQPER KFMQTFVLAP EGSVPNKFYV HNDMFRYEDE VFGDSEPELD EESEDEVEEE QEERQPSPEP VQENANSGYY EAHPVTNGIE EPLEESSHEP EPEPESETKT EELKPQVEEK NLEELEEKST TPPPAEPVSL PQEPPKPRVE AKPEVQSQPP RVREQRPRER PGFPPRGPRP GRGDMEQNDS DNRRIIRYPD SHQLFVGNLP HDIDENELKE FFMSFGNVVE LRINTKGVGG KLPNFGFVVF DDSEPVQRIL IAKPIMFRGE VRLNVEEKKT RAARERETRG GGDDRRDIRR NDRGPGGPRG IVGGGMMRDR DGRGPPPRGG MAQKLGSGRG TGQMEGRFTG QRR
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Molecular Weight
53 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
G3BP2 (Ras GTPase-activating protein SH3 domain-binding protein 2) is a crucial component in the regulation of cellular stress responses, particularly in the formation of stress granules. These granules are cytoplasmic aggregates that form during stress conditions, playing a key role in mRNA regulation and protecting cells from damage. The dysfunction of G3BP2 has been implicated in various diseases, including neurodegenerative disorders and cancer. Researchers are particularly interested in the structure and functional dynamics of G3BP2 due to its involvement in RNA binding and regulation, as well as its interactions with other signaling pathways. The study of G3BP2 recombinant proteins allows scientists to investigate these interactions and the protein's role in stress granule assembly. By producing G3BP2 in a recombinant form, researchers can explore its biochemical properties, elucidate its function in cellular processes, and identify potential therapeutic targets. Additionally, understanding the structural features of G3BP2 can enhance our knowledge of how this protein contributes to the pathophysiology of various diseases, paving the way for new strategies in drug development and therapeutic interventions. Overall, the investigation of G3BP2 recombinant proteins is vital for advancing our comprehension of cellular stress mechanisms and their implications in health and disease.
