Analytical Data
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基因名
ST14
- Application
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别名
ST14；PRSS14；SNC19；TADG15；Suppressor of tumorigenicity 14 Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y5Y6
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表达区间
1-855aa
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氨基酸序列
MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKH GPGRWVVLAAVLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNEN FVDAYENSNSTEFVSLASKVKDALKLLYSGVPFLGPYHKESAVTAFSEGS VIAYYWSEFSIPQHLVEEAERVMAEERVVMLPPRARSLKSFVVTSVVAFP TDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPAHARCQWALRG DADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGT FNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKD YVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSS DPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKF CKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDC GDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNW LVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISH PFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGW GHTQYGGTGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDS CQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIK ENTGV
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分子量
120 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The ST14 protein, also known as membrane type 14 matrix metalloproteinase (MT14-MMP), is a member of the matrix metalloproteinase family, which plays a crucial role in the degradation of the extracellular matrix (ECM). Its functional significance has garnered attention in various fields, including cancer research, wound healing, and tissue remodeling. ST14 is primarily expressed on the cell surface and is implicated in processes such as cell migration, invasion, and angiogenesis, making it a potential biomarker for tumor progression and metastasis. Studies have shown that ST14 regulates the activity of other MMPs and influences the tumor microenvironment by modulating cell interactions with the ECM. Furthermore, dysregulation of ST14 expression has been associated with several pathological conditions, including fibrosis and inflammatory diseases. Recent advancements in recombinant protein technology have enabled the production of ST14 as a recombinant protein, facilitating the exploration of its biochemical properties and therapeutic potential. Understanding the mechanisms by which ST14 affects cellular behavior and signaling pathways may provide insights into novel therapeutic strategies for diseases where aberrant ECM remodeling is a hallmark feature. Researchers are actively investigating the role of ST14 in various biological processes, aiming to elucidate its potential as a target for intervention in cancer and other disorders characterized by excessive ECM degradation or remodeling.
