Analytical Data
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基因名
CDHE
- Application
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别名
CDHE；CDHE；UVO；；Cadherin-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P12830
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表达区间
155-707aa
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氨基酸序列
DWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGV FIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTD QNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTI LSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEG LSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAP NTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHV AVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQE ITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFE HVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCE RNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKP KMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAG LQI
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分子量
64 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of recombinant CDHE (C-terminal domain of the human Epidermal Growth Factor Receptor) proteins has gained significant attention due to their potential implications in cancer therapy and cellular signaling regulation. CDHE plays a crucial role in the activation and dimerization of the EGF receptor, which is implicated in various malignancies, including breast and lung cancer. Understanding its structure and function can provide insights into the mechanisms of signal transduction pathways that govern cell proliferation, survival, and differentiation. Researchers have focused on developing recombinant CDHE proteins to explore their interactions with other cellular components and to assess their utility as therapeutic targets or biomarkers for disease progression. The advent of recombinant DNA technology has facilitated the efficient production of these proteins in various expression systems, enabling detailed functional studies and high-throughput screening for potential inhibitors. Furthermore, the structural elucidation of CDHE through techniques like X-ray crystallography and NMR has opened new avenues for rational drug design, targeting the EGF receptor's aberrant signaling in cancer cells. This research is vital not only for developing innovative cancer therapies but also for enhancing our understanding of fundamental biological processes mediated by receptor tyrosine kinases.
