Analytical Data
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基因名
INTS12
- Application
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别名
INTS12; PHF22; SBBI22; Integrator complex subunit 12; Int12; PHD finger protein 22
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96CB8
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表达区间
1-462aa
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氨基酸序列
MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPS QKDVEPPKIS STKNISIKQE PKISSSLPSG NNNGKVLTTE KVKKEAEKRP ADKMKSDITE GVDIPKKPRL EKPETQSSPI TVQSSKDLPM ADLSSFEETS ADDFAMEMGL ACVVCRQMMV ASGNQLVECQ ECHNLYHRDC HKPQVTDKEA NDPRLVWYCA RCTRQMKRMA QKTQKPPQKP APAVVSVTPA VKDPLVKKPE TKLKQETTFL AFKRTEVKTS TVISGNSSSA SVSSSVTSGL TGWAAFAAKT SSAGPSTAKL SSTTQNNTGK PATSSANQKP VGLTGLATSS KGGIGSKIGS NNSTTPTVPL KPPPPLTLGK TGLSRSVSCD NVSKVGLPSP SSLVPGSSSQ LSGNGNSGTS GPSGSTTSKT TSESSSSPSA SLKGPTSQES QLNAMKRLQM VKKKAAQKKL KK
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分子量
48.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
INTS12, a member of the Integrator complex, plays a crucial role in the regulation of gene expression, particularly in the processing of non-coding RNAs and the maturation of mRNA. Research into INTS12 has gained prominence due to its involvement in various cellular processes, including transcriptional regulation and RNA splicing. Dysregulation of INTS12 has been implicated in several diseases, including cancer, making it a significant target for therapeutic interventions. The study of recombinant INTS12 protein is essential for elucidating its biochemical properties and functional mechanisms within the Integrator complex. By producing INTS12 as a recombinant protein, researchers can investigate its interactions with other proteins and RNA, thus providing insights into its role in RNA processing and gene expression regulation. Furthermore, understanding INTS12's structure and function can help identify potential inhibitors or modulators that could serve as novel therapeutic agents for treating conditions associated with its dysregulation. Overall, the ongoing research on recombinant INTS12 protein aims to unravel its contributions to cellular homeostasis and its potential as a biomarker or therapeutic target in various diseases.
