Analytical Data
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基因名
PRPH
- Application
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别名
PRPH；PRPH；RDS；TSPAN22；Peripherin-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P41219
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表达区间
1-470aa
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氨基酸序列
MSHHPSGLRA GFSSTSYRRT FGPPPSLSPG AFSYSSSSRF SSSRLLGSAS PSSSVRLGSF RSPRAGAGAL LRLPSERLDF SMAEALNQEF LATRSNEKQE LQELNDRFAN FIEKVRFLEQ QNAALRGELS QARGQEPARA DQLCQQELRE LRRELELLGR ERDRVQVERD GLAEDLAALK QRLEEETRKR EDAEHNLVLF RKDVDDATLS RLELERKIES LMDEIEFLKK LHEEELRDLQ VSVESQQVQQ VEVEATVKPE LTAALRDIRA QYESIAAKNL QEAEEWYKSK YADLSDAANR NHEALRQAKQ EMNESRRQIQ SLTCEVDGLR GTNEALLRQL RELEEQFALE AGGYQAGAAR LEEELRQLKE EMARHLREYQ ELLNVKMALD IEIATYRKLL EGEESRISVP VHSFASLNIK TTVPEVEPPQ DSHSRKTVLI KTIETRNGEV VTESQKEQRS ELDKSSAHSY
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分子量
53.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of the PRPH (peripheral myelin protein 22) recombinant protein is rooted in its critical role in peripheral nervous system function and myelin sheath formation. PRPH is a member of the tetraspanin family, primarily expressed in Schwann cells, where it contributes to the structural integrity of myelin, essential for efficient nerve conduction. Abnormalities in PRPH expression have been linked to demyelinating diseases, such as Charcot-Marie-Tooth disease and inflammatory neuropathies, highlighting the need for detailed research into its functional properties and molecular interactions. The recombinant production of PRPH offers a valuable tool for elucidating its biological roles, as it enables the study of post-translational modifications, protein folding, and interactions with other myelin constituents. Moreover, the use of recombinant PRPH in experimental models can facilitate the development of therapeutic strategies aimed at enhancing remyelination and repairing peripheral nerve injuries. As researchers continue to uncover the mechanisms underlying PRPH's function, this work not only enhances our understanding of peripheral nerve biology but also paves the way for potential clinical applications in treating neuropathies.
