Analytical Data
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基因名
KRT17
- Application
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别名
KRT17;Keratin. type I cytoskeletal 17
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q04695
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表达区间
1-432aa
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氨基酸序列
MTTSIRQFTSSSSIKGSSGLGGGSSRTSCRLSGGLGAGSCRLGSAGGLGS TLGGSSYSSCYSFGSGGGYGSSFGGVDGLLAGGEKATMQNLNDRLASYLD KVRALEEANTELEVKIRDWYQRQAPGPARDYSQYYRTIEELQNKILTATV DNANILLQIDNARLAADDFRTKFETEQALRLSVEADINGLRRVLDELTLA RADLEMQIENLKEELAYLKKNHEEEMNALRGQVGGEINVEMDAAPGVDLS RIPNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEI SELRRTMQALEIELQSQLSMKASLEGNLAETENRYCVQLSQIQGLIGSVE EQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKK EPVTTRQVRTIVEEVQDGKVISSREQVHQTTR
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分子量
73 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT17, or Keratin 17, is a member of the keratin family and plays a crucial role in epithelial differentiation and integrity. Its expression has been linked to various physiological and pathological processes, including wound healing, skin disorders, and carcinogenesis. Research has shown that KRT17 is upregulated in response to cellular stress and injury, indicating its involvement in the repair mechanisms of epithelial tissues. Abnormal expression of KRT17 has been associated with several types of cancer, particularly squamous cell carcinoma, where it may contribute to tumor progression and metastasis. The investigation of KRT17 as a potential biomarker for cancer diagnosis and prognosis has garnered significant attention. Additionally, understanding its role in keratinocyte biology and its interaction with signaling pathways could provide insights into novel therapeutic strategies for skin-related diseases and cancer treatments. The recombination of KRT17 protein offers promising avenues for experimental studies, enabling researchers to elucidate its functional mechanisms and assess its potential in clinical applications. Overall, the multifaceted role of KRT17 in health and disease makes it a focal point of current biomedical research, aimed at unlocking new diagnostic and therapeutic possibilities.
