Analytical Data
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Gene name
ACSBG1
- Application
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Alternative Names
ACBG1_HUMAN; ACSBG 1; ACSBG1; Acyl CoA synthetase bubblegum family member 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96GR2
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Expression Region
1-724aa
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AA Sequence
MPRNSGAGYG CPHGDPSMLD SRETPQESRQ DMIVRTTQEK LKTSSLTDRQ PLSKESLNHA LELSVPEKVN NAQWDAPEEA LWTTRADGRV RLRIDPSCPQ LPYTVHRMFY EALDKYGDLI ALGFKRQDKW EHISYSQYYL LARRAAKGFL KLGLKQAHSV AILGFNSPEW FFSAVGTVFA GGIVTGIYTT SSPEACQYIA YDCCANVIMV DTQKQLEKIL KIWKQLPHLK AVVIYKEPPP NKMANVYTME EFMELGNEVP EEALDAIIDT QQPNQCCVLV YTSGTTGNPK GVMLSQDNIT WTARYGSQAG DIRPAEVQQE VVVSYLPLSH IAAQIYDLWT GIQWGAQVCF AEPDALKGSL VNTLREVEPT SHMGVPRVWE KIMERIQEVA AQSGFIRRKM LLWAMSVTLE QNLTCPGSDL KPFTTRLADY LVLAKVRQAL GFAKCQKNFY GAAPMMAETQ HFFLGLNIRL YAGYGLSETS GPHFMSSPYN YRLYSSGKLV PGCRVKLVNQ DAEGIGEICL WGRTIFMGYL NMEDKTCEAI DEEGWLHTGD AGRLDADGFL YITGRLKELI ITAGGENVPP VPIEEAVKME LPIISNAMLI GDQRKFLSML LTLKCTLDPD TSDQTDNLTE QAMEFCQRVG SRATTVSEII EKKDEAVYQA IEEGIRRVNM NAAARPYHIQ KWAILERDFS ISGGELGPTM KLKRLTVLEK YKGIIDSFYQ EQKM
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Molecular Weight
81.2 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ACSBG1, or Acyl-CoA Synthetase Bubblegum Family Member 1, is an enzyme that plays a crucial role in fatty acid metabolism and cellular energy homeostasis. This protein is part of a larger family of acyl-CoA synthetases, which are essential for the activation of fatty acids through the conversion of acyl groups to their corresponding coenzyme A derivatives. Dysregulation of ACSBG1 has been implicated in various metabolic disorders, including obesity, diabetes, and cardiovascular diseases. Recent research has focused on the structural and functional characterization of ACSBG1 to understand its role in disease mechanisms and potential therapeutic targets. Advanced techniques such as X-ray crystallography and cryo-electron microscopy have been employed to elucidate its three-dimensional structure, highlighting the enzyme's unique active site and substrate-binding characteristics. Additionally, studies have shown that ACSBG1 interacts with various metabolic pathways, influencing lipid metabolism and cellular signaling. Investigating recombinant forms of ACSBG1 allows researchers to dissect its enzymatic activity and regulatory mechanisms, paving the way for novel interventions in metabolic diseases. Understanding the biological significance of ACSBG1 not only sheds light on fundamental metabolic processes but also opens avenues for targeted therapies that could ameliorate conditions associated with dysregulated fatty acid metabolism. As the research progresses, ACSBG1 is emerging as a potential biomarker for metabolic health and a promising candidate for drug development aimed at restoring metabolic balance in affected individuals.
