Analytical Data
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基因名
gABRb3
- Application
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别名
gABRb3；Gamma-aminobutyric acid receptor subunit beta-3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P28472
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表达区间
1-473aa
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氨基酸序列
MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN
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分子量
54.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of the GABAB receptor, particularly its subunit GABABR3, has garnered significant interest in neuroscience due to its pivotal role in mediating inhibitory neurotransmission in the central nervous system. GABAB receptors are G-protein coupled receptors that respond to the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), influencing various physiological processes such as mood regulation, pain perception, and motor control. Recent research highlights the importance of the GABABR3 subunit in receptor assembly, trafficking, and functional modulation, revealing its potential implications in neurological disorders like epilepsy, anxiety, and depression. The recombinant expression of the GABABR3 protein allows for detailed structural and functional studies, providing critical insights into receptor dynamics and pharmacology. Understanding the mechanisms governing GABABR3 function could lead to the development of novel therapeutic strategies targeting GABAB receptors, thereby offering new avenues for treating disorders associated with GABAergic dysfunction. Furthermore, the ability to produce GABABR3 as a recombinant protein facilitates biophysical and biochemical analyses, essential for drug discovery and the exploration of receptor interactions in a controlled setting. Overall, ongoing research into the GABABR3 subunit is crucial for elucidating the complex role of GABAergic signaling in brain function and disease.
