Analytical Data
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基因名
TYW5
- Application
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别名
TYW5；C2orf60；tRNA wybutosine-synthesizing Protein 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A2RUC4
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表达区间
1-315aa
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氨基酸序列
MAGQHLPVPR LEGVSREQFM QHLYPQRKPL VLEGIDLGPC TSKWTVDYLS QVGGKKEVKI HVAAVAQMDF ISKNFVYRTL PFDQLVQRAA EEKHKEFFVS EDEKYYLRSL GEDPRKDVAD IRKQFPLLKG DIKFPEFFKE EQFFSSVFRI SSPGLQLWTH YDVMDNLLIQ VTGKKRVVLF SPRDAQYLYL KGTKSEVLNI DNPDLAKYPL FSKARRYECS LEAGDVLFIP ALWFHNVISE EFGVGVNIFW KHLPSECYDK TDTYGNKDPT AASRAAQILD RALKTLAELP EEYRDFYARR MVLHIQDKAY SKNSE
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TYW5 is a critical protein involved in tRNA modification, specifically in the maturation of uridine to pseudouridine in tRNA molecules. This enzymatic activity plays a vital role in proper tRNA functioning and, consequently, in protein synthesis. Recent studies have highlighted the significance of TYW5 in cellular processes and its potential implications in various diseases, including cancer and neurological disorders. The modification of tRNA is essential for maintaining the fidelity of the translation process, and disruptions in TYW5 activity can lead to translational errors and cellular stress. Additionally, researchers have identified that TYW5 interacts with other proteins and cellular pathways, suggesting its broader role in cellular homeostasis and adaptation to environmental changes. Understanding the structure-function relationship of TYW5 and its regulatory mechanisms is crucial for deciphering its biological role and potential as a therapeutic target. As such, ongoing research focuses on elucidating the detailed mechanisms of TYW5, exploring its involvement in specific diseases, and investigating the potential for manipulating TYW5 activity in therapeutic settings. This growing body of knowledge aims to pave the way for innovative approaches in combating diseases linked to tRNA modification dysregulation.
