Analytical Data
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基因名
UBE2C
- Application
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别名
UBE2C；UBCH10；Ubiquitin-conjugating enzyme E2 C
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00762
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表达区间
2-179aa
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氨基酸序列
ASQNRDPAA TSVAAARKGA EPSGGAARGP VGKRLQQELM TLMMSGDKGI SAFPESDNLF KWVGTIHGAA GTVYEDLRYK LSLEFPSGYP YNAPTVKFLT PCYHPNVDTQ GNICLDILKE KWSALYDVRT ILLSIQSLLG EPNIDSPLNT HAAELWKNPT AFKKYLQETY SKQVTSQEP
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分子量
21 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBE2C, a member of the ubiquitin-conjugating enzyme family, plays a crucial role in the ubiquitin-proteasome system, which regulates protein degradation and signaling pathways within cells. This enzyme is involved in the post-translational modification of target proteins by transferring ubiquitin molecules, thereby marking them for degradation or altering their functional properties. Abnormal UBE2C expression has been implicated in various diseases, particularly cancer, where it is often overexpressed, contributing to tumorigenesis by promoting the degradation of tumor suppressor proteins. Research into recombinant UBE2C protein aims to elucidate its molecular mechanisms and interactions with other cellular components. By producing UBE2C in a recombinant form, scientists can study its enzymatic activity, binding affinity to substrates, and its impact on cellular pathways in a controlled environment. Additionally, understanding UBE2C's role in cancer biology holds potential for therapeutic interventions, as targeting UBE2C may restore normal protein degradation processes and inhibit cancer progression. Further studies using UBE2C recombinant protein could facilitate the development of novel cancer treatments and contribute to the broader understanding of ubiquitin-mediated regulation in various biological contexts.
