Analytical Data
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基因名
ARMET
- Application
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别名
ARP; Manf; MANF_HUMAN; Mesencephalic astrocyte derived neurotrophic factor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P55145
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表达区间
25-182aa
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氨基酸序列
LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL
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分子量
18.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARMET (activity-regulated member of the ERM family) is a protein that plays a crucial role in the regulation of neuroplasticity and synaptic function. It is predominantly expressed in the brain and has been implicated in various cellular processes, including the modulation of synaptic strength and the facilitation of long-term potentiation, which are essential for learning and memory. Research into ARMET has gained momentum due to its potential involvement in neurodegenerative diseases and psychiatric disorders, where alterations in synaptic plasticity are often observed. Studies have demonstrated that ARMET can be regulated by neuronal activity, suggesting that it acts as a mediating factor in the signaling pathways associated with neuronal responses to external stimuli. Recent investigations have focused on elucidating the molecular mechanisms by which ARMET influences neuronal health and function, including its interactions with other proteins in the signaling cascade. The understanding of ARMET's role could lead to novel therapeutic strategies for addressing cognitive impairments and emotional disorders linked to dysfunctional synaptic plasticity. As the field of neuroscience continues to evolve, further research into ARMET and its regulatory functions offers promising avenues for exploring the complexities of brain function and the underlying mechanisms of neurological diseases.












