Analytical Data
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基因名
PCGF6
- Application
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别名
MBLR; Mel18 and Bmi1 like RING finger protein; Mel18 and Bmi1-like RING finger; Pcgf6; PCGF6_HUMAN; Polycomb group RING finger protein 6; RING finger protein 134; RNF134
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BYE7
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表达区间
1-350 aa
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氨基酸序列
MEGVAVVTAG SVGAAKTEGA AALPPPPPVS PPALTPAPAA GEEGPAPLSE TGAPGCSGSR PPELEPERSL GRFRGRFEDE DEELEEEEEL EEEEEEEEED MSHFSLRLEG GRQDSEDEEE RLINLSELTP YILCSICKGY LIDATTITEC LHTFCKSCIV RHFYYSNRCP KCNIVVHQTQ PLYNIRLDRQ LQDIVYKLVI NLEEREKKQM HDFYKERGLE VPKPAVPQPV PSSKGRSKKV LESVFRIPPE LDMSLLLEFI GANEGTGHFK PLEKKFVRVS GEATIGHVEK FLRRKMGLDP ACQVDIICGD HLLEQYQTLR EIRRAIGDAA MQDGLLVLHY GLVVSPLKIT
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分子量
39.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCGF6 (Polycomb group RING finger 6) is a member of the Polycomb group (PcG) proteins, which play a crucial role in epigenetic regulation of gene expression, primarily through histone modification and chromatin remodeling. The study of PCGF6 is particularly relevant due to its involvement in development, cell differentiation, and its potential link to various diseases, including cancers. Research indicates that PCGF6 can function as a transcriptional repressor, influencing lineage commitment and maintaining stem cell pluripotency. Understanding the mechanisms and pathways involving PCGF6 is essential for uncovering its roles in cellular processes and its implications in tumorigenesis and other pathological conditions. The recombinant expression of PCGF6 protein enables researchers to investigate its biochemical properties, interactions with other protein complexes, and its functional significance in cellular contexts. Advances in protein engineering and expression techniques facilitate the production of PCGF6 in sufficient quantities for structural and functional studies, paving the way for therapeutic applications and providing insights into its role in epigenetic regulation. Consequently, research on PCGF6 recombinant protein is vital for elucidating the intricate networks of gene regulation, contributing to the development of targeted therapies in regenerative medicine and oncology.
