Analytical Data
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基因名
ASAH3L
- Application
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别名
ACER2; ASAH3L; PP11646; Alkaline ceramidase 2; AlkCDase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5QJU3
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表达区间
1-226aa
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氨基酸序列
MCLFRQYATCFNSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAVLWVLMCALAMWFPRRYLPKIFRNDRGRFKVVVSVLSAVTTCLAFVKPAINNISLMTLGVPCTALLIAELKRCDNMRVFKLGLFSGLWWTLALFCWISDRAFCELLSSFNFPYLHCMWHILICLAAYLGCVCFAYFDAASEIPEQGPVIKFWPNEKWAFIGVPYVSLLCANKKSSVKIT
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分子量
52.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ASAH3L, or acid ceramidase-like enzyme, belongs to the family of enzymes involved in sphingolipid metabolism, which plays a critical role in cellular signaling, proliferation, and apoptosis. This enzyme is particularly interesting due to its unique structure and potential functional roles that differ from its well-characterized counterpart, acid ceramidase (ASAH1). Research into ASAH3L has gained momentum because of its implications in various pathological conditions, including cancer, neurodegenerative diseases, and metabolic disorders. Despite the potential significance of ASAH3L in health and disease, there remains a limited understanding of its specific biochemical properties, regulatory mechanisms, and physiological roles. Recent studies have aimed to elucidate the enzyme's structure-function relationships, substrate specificity, and involvement in cellular processes. Additionally, as researchers explore the pathways associated with sphingolipid metabolism, ASAH3L emerges as a potential therapeutic target. By better understanding its function, we may uncover novel strategies for manipulating lipid signaling pathways in disease contexts, further reinforcing the importance of continued investigation into this enigmatic enzyme.
