Analytical Data
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基因名
GNaO1
- Application
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别名
GNaO1；Guanine nucleotide-binding Protein G(o) subunit alpha
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种属
Mouse
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P18872
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表达区间
2-354aa
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氨基酸序列
GCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGVEYGDKERKTDSKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAGDYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYPGSNTYEDAAAYIQTQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
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分子量
42.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNaO1, a member of the GTPase family, plays a crucial role in cellular signaling pathways, particularly in the regulation of neurotransmitter release and synaptic plasticity. Recent studies have highlighted its involvement in various neurological disorders, including schizophrenia and bipolar disorder, making it a significant target for therapeutic intervention. The recombinant expression of GNaO1 in various model systems, such as bacteria and yeast, allows researchers to produce and purify this protein for in-depth functional studies. Understanding the structural and functional properties of GNaO1 helps elucidate its role in intracellular signaling and provides insights into its interactions with other proteins. Additionally, characterizing the protein’s binding affinity for GTP and GDP can shed light on its regulatory mechanisms and contribute to drug discovery efforts aimed at modulating its activity. Given its potential implications in neuropharmacology, the study of GNaO1 recombinant protein is essential for advancing our knowledge of molecular mechanisms underlying neurodevelopmental and psychiatric disorders.
