Analytical Data
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基因名
PPFIA4
- Application
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别名
KIAA0897; LIPA4_HUMAN; Liprin alpha 4; Liprin-alpha-4; PPFIA 4; PPFIA4; Protein tyrosine phosphatase receptor type f polypeptide (PTPRF) interacting protein (liprin) alpha 4; Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 4; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4; PTPRF interacting protein alpha 4; PTPRF-interacting protein alpha-4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75335
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表达区间
1-701 aa
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氨基酸序列
MGSAADVRFS LGTTTHAPPG VHRRYSALRE ESAKDWETSP LPGMLAPAAG PAFDSDPEIS DVDEDEPGGL VGSADVVSPS GHSDAQTLAM MLQEQLDAIN EEIRMIQEEK ESTELRAEEI ETRVTSGSME ALNLKQLRKR GSIPTSLTAL SLASASPPLS GRSTPKLTSR SAAQDLDRMG VMTLPSDLRK HRRKLLSPVS REENREDKAT IKCETSPPSS PRTLRLEKLG HPALSQEEGK SALEDQGSNP SSSNSSQDSL HKGAKRKGIK SSIGRLFGKK EKGRLIQLSR DGATGHVLLT DSEFSMQEPM VPAKLGTQAE KDRRLKKKHQ LLEDARRKGM PFAQWDGPTV VSWLELWVGM PAWYVAACRA NVKSGAIMSA LSDTEIQREI GISNALHRLK LRLAIQEMVS LTSPSAPPTS RTSSGNVWVT HEEMETLETS TKTDSEEGSW AQTLAYGDMN HEWIGNEWLP SLGLPQYRSY FMECLVDARM LDHLTKKDLR VHLKMVDSFH RTSLQYGIMC LKRLNYDRKE LEKRREESQH EIKDVLVWTN DQVVHWVQSI GLRDYAGNLH ESGVHGALLA LDENFDHNTL ALILQIPTQN TQARQVMERE FNNLLALGTD RKLDDGDDKV FRRAPSWRKR FRPREHHGRG GMLSASAETL PAGFRVSTLG TLQPPPAPPK KIMPEAHSHY LYGHMLSAFR D
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分子量
134.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPFIA4, also known as Protein Phosphatase 1, regulatory subunit 14, plays a crucial role in various cellular processes, including signal transduction, neuronal development, and synaptic function. It is part of the protein phosphatase 1 (PP1) family, which is integral to the regulation of numerous physiological pathways by dephosphorylating serine and threonine residues on target proteins. Research on PPFIA4 has garnered attention due to its implications in neurobiology, particularly in relation to cognitive functions and synaptic plasticity, which are fundamental for learning and memory. Additionally, emerging studies indicate that alterations in PPFIA4 expression or function may be linked to several neurological disorders, including Alzheimer's disease and schizophrenia. The exploration of PPFIA4 as a potential therapeutic target has led to increased interest in its structural characteristics, interaction partners, and regulatory mechanisms. Understanding the biochemical properties and functional roles of the PPFIA4 recombinant protein is essential for delineating its contribution to cellular signaling networks and its potential role in disease mechanisms. This research could pave the way for novel therapeutic approaches aimed at modulating PP1 activity in the context of neurodegenerative diseases and other disorders associated with dysregulated phosphorylation processes.
