Analytical Data
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基因名
PPP1R14B
- Application
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别名
PHI 1; PHI1; Phospholipase C beta 3 neighboring gene protein; Phospholipase C beta 3 neighbouring gene protein; Phospholipase C-beta-3 neighbouring gene protein; PLCB3N; PNG ; PP14B_HUMAN; Ppp1r14b; Protein phosphatase 1 regulatory (inhibitor) subunit 14B; Protein phosphatase 1 regulatory subunit 14B; SOM172
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96C90
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表达区间
2-147 aa
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氨基酸序列
ADSGTAGGA ALAAPAPGPG SGGPGPRVYF QSPPGAAGEG PGGADDEGPV RRQGKVTVKY DRKELRKRLN LEEWILEQLT RLYDCQEEEI PELEIDVDEL LDMESDDARA ARVKELLVDC YKPTEAFISG LLDKIRGMQK LSTPQKK
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分子量
15.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPP1R14B, or Protein Phosphatase 1 Regulatory Subunit 14B, is a member of the family of regulatory subunits that modulate the activity of protein phosphatase 1 (PP1), a key enzyme involved in various cellular processes, including cell division, muscle contraction, and signal transduction. The regulation of PP1 by its regulatory subunits is crucial for maintaining cellular homeostasis and responding to external stimuli. Research into PPP1R14B is particularly relevant because it has been implicated in several pathological conditions, including cancer and neurological disorders, where aberrant regulation of PP1 activity may contribute to disease progression. Additionally, PPP1R14B is known to play a role in the regulation of myosin light chain phosphatase, influencing smooth muscle contraction and other cellular motility processes. Given its important regulatory functions, the recombinant expression and characterization of PPP1R14B provide vital insights into its molecular mechanism and potential therapeutic applications. Understanding the structure and function of this protein is essential for elucidating its role in regulating PP1 activity, paving the way for targeted interventions in PP1-related diseases. The investigation of PPP1R14B as a recombinant protein allows researchers to study its interactions, post-translational modifications, and influence on cell signaling pathways in a controlled environment, ultimately contributing to the broader understanding of the regulatory networks within cells.
