Analytical Data
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基因名
HTR3D
- Application
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别名
HTR3D;5-hydroxytryptamine receptor 3D
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q70Z44
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表达区间
221-454aa
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氨基酸序列
VAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVAPLALMQTPLPAGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT
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分子量
41.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HTR3D, a member of the 5-HT receptor family, plays a crucial role in neurotransmission and various physiological functions, including mood regulation and cognition. Research on recombinant HTR3D proteins is gaining traction due to their significance in understanding serotonin signaling pathways and their implications in treating psychiatric disorders. The study of HTR3D is particularly relevant in the context of the increasing incidence of mental health issues globally, as well as the need for targeted therapies that can mitigate side effects associated with traditional antidepressants. Previous studies have highlighted the potential of HTR3D in modulating neuromodulatory systems, thereby influencing neurotransmitter release and synaptic plasticity. In vitro expression systems have been utilized to produce recombinant HTR3D proteins, enabling detailed biochemical and pharmacological characterizations. These studies aim to elucidate the receptor's structural features, ligand-binding properties, and functional responses, which are essential for drug discovery. As researchers continue to explore the therapeutic targets within the serotonin receptor family, HTR3D stands out as a promising candidate for further investigation, particularly in the development of novel anxiolytics and antidepressants. Understanding the precise mechanisms of HTR3D could pave the way for innovative treatments, ultimately improving the quality of life for individuals suffering from serotonin-related disorders.












