Analytical Data
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基因名
C12orf2
- Application
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别名
C12orf2; Carcinoma associated HOJ 1; Carcinoma associated Protein HOJ 1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NHQ8
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表达区间
1-392aa
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氨基酸序列
MELKVWVDGVQRIVCGVTEVTTCQEVVIALAQAIGRTGRYTLIEKWRDTERHLAPHENPIISLNKWGQYASDVQLILRRTGPSLSERPTSDSVARIPERTLYRQSLPPLAKLRPQIDKSIKRREPKRKSLTFTGGAKGLMDIFGKGKETEFKQKVLNNCKTTADELKKLIRLQTEKLQSIEKQLESNEIEIRFWEQKYNSNLEEEIVRLEQKIKRNDVEIEEEEFWENELQIEQENEKQLKDQLQEIRQKITECENKLKDYLAQIRTMESGLEAEKLQREVQEAQVNEEEVKGKIGKVKGEIDIQGQQSLRLENGIKAVERSLGQATKRLQDKEQELEQLTKELRQVNLQQFIQQTGTKVTVLPAEPIEIEASHADIERGIIILSDKQECKD
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分子量
68.86 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C12orf2, also known as the TERT-like gene, encodes a protein that is a critical component of the telomerase complex, responsible for maintaining telomere length and stability in eukaryotic cells. Understanding the function and regulation of C12orf2 is crucial due to its association with cellular aging and the potential implications in cancer biology. Telomeres, which shorten with each cell division, play a significant role in limiting cellular proliferation, and thus, the activity of telomerase, in which C12orf2 is involved, can influence tumorigenesis. Recent studies have demonstrated that alterations in C12orf2 expression can lead to increased cell proliferation and resistance to apoptosis, highlighting its significance in various cancers. Moreover, C12orf2 has been linked to other cellular processes such as DNA repair and maintenance of genomic integrity, further underscoring its importance in cellular homeostasis. Given these factors, the investigation of C12orf2 as a potential therapeutic target or biomarker in cancer treatment is of great interest, as it may offer new insights into the mechanisms of tumor growth and progression. Thus, ongoing research into C12orf2 not only enhances our understanding of fundamental cellular biology but also opens avenues for innovative approaches in cancer therapeutics.
