Recombinant Human PERP Protein，His

PERP (p53 apoptosis effector related to PMP-22) is a member of the tetraspanin family and has garnered significant attention in cancer research due to its role in mediating cellular responses influenced by the tumor suppressor protein p53. Initially identified as a gene that responds to p53 activation, PERP is implicated in processes such as apoptosis, cell adhesion, and tissue differentiation. Studies have shown that PERP expression is often downregulated in various types of tumors, suggesting a potential role as a tumor suppressor. Its involvement in the p53 pathway highlights the importance of preserving its function for maintaining genomic stability and preventing tumorigenesis. Moreover, PERP has also been linked to the regulation of cellular senescence, thus providing insights into its role in aging and age-related diseases. As researchers continue to elucidate the molecular mechanisms underlying PERP function, therapeutic strategies aimed at restoring its activity in tumor cells are being explored. This could offer new avenues for cancer treatment, particularly in cases where p53 is functional but its downstream effectors, like PERP, are lost or impaired. Overall, the ongoing exploration of PERP, including its structure, regulatory mechanisms, and interactions with other proteins, aims to deepen our understanding of its critical functions in both normal physiology and disease.