Analytical Data
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Gene name
C14orf130
- Application
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Alternative Names
UBR7; C14orf130; Putative E3 ubiquitin-Protein ligase UBR7; EC 2.3.2.27; N-recognin-7; RING-type E3 ubiquitin transferase UBR7
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N806
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Expression Region
1-425aa
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AA Sequence
MIQCVVCEDWFHGRHLGAIPPESGDFQEMVCQACMKRCSFLWAYAAQLAVTKISTEDDGLVRNIDGIGDQEVIKPENGEHQDSTLKEDVPEQGKDDVREVKVEQNSEPCAGSSSESDLQTVFKNESLNAESKSGCKLQELKAKQLIKKDTATYWPLNWRSKLCTCQDCMKMYGDLDVLFLTDEYDTVLAYENKGKIAQATDRSDPLMDTLSSMNRVQQVELICEYNDLKTELKDYLKRFADEGTVVKREDIQQFFEEFQSKKRRRVDGMQYYCS
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Molecular Weight
57.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C14orf130, also known as TBC1D17, has emerged as a significant protein in cellular biology due to its involvement in various cellular processes, including endosomal trafficking and autophagy. This protein is encoded by the chromosome 14 open reading frame 130 gene and has garnered attention for its role in modulating the dynamics of cellular membranes and its potential implications in diseases such as cancer and neurodegenerative disorders. Recent studies suggest that C14orf130 may act as a GTPase-activating protein (GAP) for the Rab family of small GTPases, which are crucial regulators of vesicular transport. The structural characterization of recombinant C14orf130 has become a focus of research to better understand its functional mechanisms and potential interactions with other cellular components. By producing and studying recombinant C14orf130, researchers aim to elucidate its role in disease pathways and identify possible therapeutic targets. Understanding the structure-function relationship of this protein is essential for deciphering its biological roles and could pave the way for novel interventions in related pathologies. The ongoing research on C14orf130 not only enhances our grasp of fundamental cellular mechanisms but also opens new avenues for therapeutic development in diseases where vesicular trafficking is disrupted.
