Analytical Data
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基因名
SENP7
- Application
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别名
SENP7；KIAA1707；SSP2；SUSP2；Sentrin-specific protease 7
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BQF6
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表达区间
695-864aa
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氨基酸序列
MKLKSVSQPSNTDAAKPTYTFLQKQSSGCYSLSITSNPDEEWREVRHTGLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTWTRHINIFNKDYIFVPVNESSHWYLA
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SENP7 (Sentrin/SUMO-specific protease 7) is a member of the SENP family of proteases, which play crucial roles in the post-translational modification of proteins through SUMOylation— the attachment of Small Ubiquitin-like Modifier (SUMO) proteins. This modification regulates various cellular processes, including signal transduction, transcriptional control, and response to stress. The study of SENP7 has gained significant attention due to its implications in diverse biological functions and disease mechanisms, particularly in cancer progression and neurodegenerative disorders. Research has shown that SENP7 can remove SUMO chains, thereby regulating the stability and activity of target proteins. Dysregulation of SENP7 activity has been implicated in the pathogenesis of several diseases, leading to increased interest in its potential as a therapeutic target. Furthermore, explorations into the biochemical properties, substrate specificity, and interaction networks of SENP7 are ongoing, providing insights into its functional roles within the cell. Understanding SENP7's mechanisms and effects on cellular pathways is vital for developing novel strategies in disease treatment and therapy.
