Analytical Data
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基因名
Ikzf2
- Application
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别名
Ikzf2；HELIOS；ZNFN1A2；Zinc finger Protein Helios
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKS7
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表达区间
1-500aa
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氨基酸序列
METEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEVADNRKVQELQGEGGIRLPNGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVIEKLTGNMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYSQVYHPNRIERPISRETADSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDTTKAPKGSLKDIYKVFNGEGEQIRAFKCEHCRVLFLDHVMYTIHMGCHGYRDPLECNICGYRSQDRYEFSSHIVRGEHTFH
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分子量
59.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Ikzf2, also known as Ikaros, is a member of the Ikaros family of zinc finger proteins that play crucial roles in the development and regulation of the immune system, particularly in T and B cell differentiation. Research has shown that Ikzf2 is essential for proper lymphocyte function, as it regulates gene expression critical for immune response and cell fate determination. Dysregulation of Ikzf2 has been implicated in various hematological malignancies, including leukemia and lymphoma, making it a potential target for therapeutic intervention. The recombinant expression of Ikzf2 protein allows for the detailed study of its structure, function, and interactions with other cellular components. Understanding these interactions can provide insights into the mechanisms underlying immune system regulation and the pathogenesis of related diseases. Furthermore, generating recombinant Ikzf2 enables the development of assays to screen for small molecules or other compounds that may modulate its activity, offering new avenues for targeted therapies in cancer treatment. Overall, the research on Ikzf2 recombinant protein is significant for both basic immunology and clinical applications, shedding light on potential strategies for manipulating immune responses in various disease contexts.
