Analytical Data
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基因名
PSMD3
- Application
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别名
26S proteasome non ATPase regulatory subunit 3; 26S proteasome non-ATPase regulatory subunit 3; 26S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; OTTHUMP00000164347; P58; Proteasome (prosome. macropain) 26S subunit non ATPase 3; Proteasome subunit p58; PSMD3; PSMD3_HUMAN; RPN3; S3; Tissue specific transplantation antigen 2; TSTA2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43242
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表达区间
1-534 aa
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氨基酸序列
MKQEGSARRR GADKAKPPPG GGEQEPPPPP APQDVEMKEE AATGGGSTGE ADGKTAAAAA EHSQRELDTV TLEDIKEHVK QLEKAVSGKE PRFVLRALRM LPSTSRRLNH YVLYKAVQGF FTSNNATRDF LLPFLEEPMD TEADLQFRPR TGKAASTPLL PEVEAYLQLL VVIFMMNSKR YKEAQKISDD LMQKISTQNR RALDLVAAKC YYYHARVYEF LDKLDVVRSF LHARLRTATL RHDADGQATL LNLLLRNYLH YSLYDQAEKL VSKSVFPEQA NNNEWARYLY YTGRIKAIQL EYSEARRTMT NALRKAPQHT AVGFKQTVHK LLIVVELLLG EIPDRLQFRQ PSLKRSLMPY FLLTQAVRTG NLAKFNQVLD QFGEKFQADG TYTLIIRLRH NVIKTGVRMI SLSYSRISLA DIAQKLQLDS PEDAEFIVAK AIRDGVIEAS INHEKGYVQS KEMIDIYSTR EPQLAFHQRI SFCLDIHNMS VKAMRFPPKS YNKDLESAEE RREREQQDLE FAKEMAEDDD DSFP
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分子量
60.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMD3, a subunit of the 26S proteasome, plays a crucial role in the ubiquitin-proteasome system, which is essential for protein degradation and regulation of cellular processes. The dysregulation of this system is implicated in various diseases, including cancer and neurodegenerative disorders. Recent research has highlighted the importance of PSMD3 in modulating proteasome activity and its involvement in the degradation of key regulatory proteins that control cell cycle, apoptosis, and signal transduction pathways. Given its pivotal function, PSMD3 is emerging as a potential therapeutic target for enhancing proteasome activity in diseases where protein misfolding and accumulation occur. The production of recombinant PSMD3 protein allows for in-depth biochemical and structural studies, providing insights into its functional mechanisms and interactions within the proteasome complex. These studies contribute to the understanding of the role of PSMD3 in cellular homeostasis and may guide the development of novel strategies for therapeutic intervention in proteasome-related diseases.
