Analytical Data
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基因名
FGFR3
- Application
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别名
FGFR3；JTK4；Fibroblast growth factor receptor 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P22607
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表达区间
23-375aa
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氨基酸序列
ESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPT VWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFS VRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTV RFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSD RGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVE FHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELE VLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSV YAG
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fibroblast growth factor receptor 3 (FGFR3) is a crucial regulator of bone and cartilage development, playing a significant role in skeletal growth and maintenance. Mutations in the FGFR3 gene are associated with several skeletal dysplasias, most notably achondroplasia, the most common form of dwarfism. Research surrounding FGFR3 has gained considerable attention due to its implications in developmental biology and potential therapeutic targets for related disorders. The understanding of FGFR3's structure and function has been advanced through the study of recombinant FGFR3 proteins. These proteins are produced using recombinant DNA technology, allowing researchers to obtain large quantities of the protein for detailed biochemical and structural analysis. This has facilitated investigations into the signaling pathways activated by FGFR3, how mutations alter its function, and the development of pharmacological agents that can modulate FGFR3 activity. Moreover, recombinant FGFR3 proteins serve as valuable tools in drug discovery and engineering novel therapeutic strategies. By elucidating the molecular mechanisms behind FGFR3-related skeletal disorders, researchers aim to develop effective treatments that can ameliorate the consequences of these genetic mutations and enhance the quality of life for affected individuals. Overall, the study of FGFR3 recombinant proteins is essential for advancing our understanding of skeletal biology and the potential therapeutic avenues to address FGFR3-related conditions.
