Analytical Data
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基因名
RAB7
- Application
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别名
CMT2B ; PRO2706; PSN; RAB7; member RAS oncogene family; RAB7A; RAB7A; member RAS oncogene family; RAB7A_HUMAN; Ras associated protein RAB7 ; Ras related protein Rab7; Ras related protein Rab7a; Ras-related protein Rab-7a
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51149
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表达区间
1-207 aa
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氨基酸序列
MTSRKKVLLK VIILGDSGVG KTSLMNQYVN KKFSNQYKAT IGADFLTKEV MVDDRLVTMQ IWDTAGQERF QSLGVAFYRG ADCCVLVFDV TAPNTFKTLD SWRDEFLIQA SPRDPENFPF VVLGNKIDLE NRQVATKRAQ AWCYSKNNIP YFETSAKEAI NVEQAFQTIA RNALKQETEV ELYNEFPEPI KLDKNDRAKA SAESCSC
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分子量
23.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Rab7 is a member of the Rab GTPase family, which plays a crucial role in regulating intracellular vesicle trafficking, particularly in the late endosomal and lysosomal pathways. This small GTPase is essential for the maturation of endosomes, the fusion of late endosomes with lysosomes, and the degradation of cellular components. Research has shown that Rab7 is implicated in various cellular processes, including autophagy, nutrient sensing, and the transport of signaling molecules. Dysregulation of Rab7 has been linked to several diseases, including neurodegenerative disorders, cancer, and infections, making it a significant target for therapeutic interventions. The study of recombinant Rab7 proteins has gained attention for elucidating its functional mechanisms and interactions with other cellular proteins. By expressing and purifying Rab7 in a heterologous system, researchers can investigate its GTPase activity, binding partners, and role in cellular dynamics. Understanding the structural and functional properties of Rab7 promotes insights into its contributions to cellular homeostasis and pathogenesis, paving the way for potential drug discovery and development strategies aimed at modulating Rab7 activity in various disease contexts. Thus, the study of recombinant Rab7 proteins not only enhances our understanding of fundamental cellular biology but also holds promise for clinical applications in treating Rab7-associated diseases.
