Analytical Data
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基因名
ITK
- Application
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别名
ITK；EMT；LYK；Tyrosine-Protein kinase ITK/TSK
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q08881
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表达区间
1-620aa
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氨基酸序列
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRT LKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQ RWVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTK NASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCL LDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAE KLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVT AGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAM SEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLR TQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKV SDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLM WEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKER PEDRPAFSRLLRQLAEIAESGL
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分子量
108 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ITK (Interleukin-2-inducible T-cell kinase) is a critical protein in the regulation of T-cell signaling and function, particularly in the immune response. Its importance lies in its role as a non-receptor tyrosine kinase that mediates various signaling pathways essential for T-cell activation, differentiation, and survival. Research on ITK has gained momentum due to its implications in various diseases, including autoimmune disorders, chronic inflammation, and certain cancers. Understanding the structure and function of ITK is vital for elucidating its role in T-cell dynamics and for the development of targeted therapies. Recombinant versions of ITK have been engineered to study its interactions with other proteins and to identify potential pharmacological targets. By exploring the biochemical properties and regulatory mechanisms of ITK, researchers aim to harness its therapeutic potential, providing new avenues for treating conditions linked to immune dysregulation. This research not only contributes to the basic understanding of T-cell biology but also holds promise for innovative treatment strategies in immunotherapy.
