Analytical Data
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基因名
RCC1
- Application
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别名
Cell cycle regulatory protein; CHC 1; CHC1; Chromosome condensation 1; Chromosome condensation protein 1; Guanine nucleotide releasing protein; HERC2; Ran GEF; RanGEF; RCC 1; RCC1; RCC1 I; RCC1_HUMAN; Regulator of chromosome condensation 1; Regulator of chromosome condensation; SHEP1; SNHG3 RCC1; SNHG3 RCC1 readthrough transcript
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P18754
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表达区间
2-421 aa
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氨基酸序列
SPKRIAKRR SPPADAIPKS KKVKVSHRSH STEPGLVLTL GQGDVGQLGL GENVMERKKP ALVSIPEDVV QAEAGGMHTV CLSKSGQVYS FGCNDEGALG RDTSVEGSEM VPGKVELQEK VVQVSAGDSH TAALTDDGRV FLWGSFRDNN GVIGLLEPMK KSMVPVQVQL DVPVVKVASG NDHLVMLTAD GDLYTLGCGE QGQLGRVPEL FANRGGRQGL ERLLVPKCVM LKSRGSRGHV RFQDAFCGAY FTFAISHEGH VYGFGLSNYH QLGTPGTESC FIPQNLTSFK NSTKSWVGFS GGQHHTVCMD SEGKAYSLGR AEYGRLGLGE GAEEKSIPTL ISRLPAVSSV ACGASVGYAV TKDGRVFAWG MGTNYQLGTG QDEDAWSPVE MMGKQLENRV VLSVSSGGQH TVLLVKDKEQ S
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分子量
44.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RCC1 (Regulator of Chromosome Condensation 1) is a vital protein that plays a crucial role in the regulation of the cell cycle and chromosome condensation, particularly during mitosis. It functions as a guanine nucleotide exchange factor (GEF) for the small GTPase Ran, facilitating the conversion of RanGDP to RanGTP, which is essential for the transport of proteins and RNA across the nuclear envelope. The study of RCC1 has become increasingly important in cancer research, as aberrations in RCC1 expression or function can lead to genomic instability, a hallmark of cancer cells. Furthermore, RCC1 is implicated in various cellular processes, including DNA repair, mitotic spindle assembly, and nuclear organization, making it a significant target for therapeutic interventions. Researchers are focused on understanding the molecular mechanisms underlying RCC1's functions and its interactions with other proteins, as well as exploring its potential as a biomarker for cancer prognosis and treatment response. Advances in recombinant protein technology have enabled the production of purified RCC1 for in vitro studies, revealing insights into its biochemical activities and role in cellular processes. These efforts contribute to a growing body of evidence that positions RCC1 as a pivotal player in maintaining chromosomal integrity, highlighting its importance in both basic biology and potential clinical applications.
