Analytical Data
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基因名
CALCR
- Application
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别名
CALCR; Calcitonin receptor; CT-R
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P30988
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表达区间
1-474aa
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氨基酸序列
MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYICHQELRNEPANNQGEESAEIIPLNIIEQESSA
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分子量
81.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CALCR, or Calcitonin Receptor, is a G-protein-coupled receptor involved in calcium homeostasis and bone metabolism. Its significance has gained attention in the context of various physiological and pathological conditions, including osteoporosis and chronic pain. The receptor mediates the effects of calcitonin, a peptide hormone that plays a critical role in decreasing bone resorption and regulating serum calcium levels. Research on the recombinant expression of CALCR protein is crucial for understanding its structure-function relationship and signaling mechanisms. Generating CALCR as a recombinant protein offers an avenue for detailed biochemical and pharmacological studies, enabling the evaluation of ligand-receptor interactions and the exploration of novel therapeutic strategies. Such studies could lead to the development of new drugs targeting CALCR for the treatment of bone-related diseases and metabolic disorders. Moreover, understanding the receptor's role in signaling pathways may reveal potential targets for treating pain syndromes, thereby expanding the therapeutic applications of CALCR-related compounds. The ability to produce high-quality CALCR protein through recombinant technology is a key step in advancing both basic research and clinical applications, contributing to the broader field of endocrinology and metabolism.
