Analytical Data
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Gene name
CARD14
- Application
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Alternative Names
Bcl10 interacting MAGUK Protein 2; Bimp 2; Bimp2 ; CAR14_HUMAN; CARD 14; CARD containing MAGUK 2 Protein; CARD containing MAGUK Protein 2; Card maguk Protein 2; CARD-containing MAGUK Protein 2; CARD14; Carma 2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BXL6
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Expression Region
1-434aa
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AA Sequence
MVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPAPPSQQSLYKRVAEDFGEEPWSFSSCLEIPEGDPGALPGAKAGDPHLDYELLDTADLPQLESSLQPVSPGRLDVSESGVLMRRRPARRILSQVTMLAFQGDALLEQISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVSRARPLLSPGLLMGTVAAGGVTQADFTSPRRCRSTLGWASALSWADVKRSAHL
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Molecular Weight
74.9 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CARD14, a member of the caspase recruitment domain (CARD) family, has garnered significant attention in recent years due to its pivotal role in the innate immune response, particularly in the context of psoriasis and other inflammatory skin disorders. It acts as an essential mediator of NF-κB signaling pathway activation, which is critical for orchestrating inflammatory responses. Mutations in the CARD14 gene have been linked to autoinflammatory diseases, highlighting its importance in maintaining immune homeostasis. Research has demonstrated that CARD14 is involved in the activation of pro-inflammatory cytokines and chemokines, contributing to the pathogenesis of various skin conditions. Furthermore, the study of CARD14 has implications for therapeutic interventions, as targeting its pathways may offer new strategies for treating psoriasis and related disorders. Understanding the structural and functional characteristics of CARD14 is crucial for deciphering the molecular mechanisms underlying its role in inflammation and autoimmune responses. Thus, the exploration of CARD14 recombinant proteins provides a valuable tool for elucidating its biological functions and potentially developing targeted therapies.
