Analytical Data
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基因名
RNF138
- Application
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别名
E3 ubiquitin protein ligase RNF138; E3 ubiquitin-protein ligase RNF138; hNARF; HSD 4; HSD4; MGC8758; NARF; Nemo like kinase associated RING finger protein; Nemo-like kinase-associated RING finger protein; NLK associated RING finger protein; NLK-associated RING finger protein; RING finger protein 138; ring finger protein 138. E3 ubiquitin protein ligase; RN138_HUMAN; Rnf138; STRIN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WVD3
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表达区间
2-245 aa
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氨基酸序列
AEDLSAATS YTEDDFYCPV CQEVLKTPVR TTACQHVFCR KCFLTAMRES GAHCPLCRGN VTRRERACPE RALDLENIMR KFSGSCRCCA KQIKFYRMRH HYKSCKKYQD EYGVSSIIPN FQISQDSVGN SNRSETSTSD NTETYQENTS SSGHPTFKCP LCQESNFTRQ RLLDHCNSNH LFQIVPVTCP ICVSLPWGDP SQITRNFVSH LNQRHQFDYG EFVNLQLDEE TQYQTAVEES FQVNI
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分子量
28.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNF138, a member of the RING-finger protein family, has gained significant attention in recent years due to its potential roles in various cellular processes, including protein ubiquitination, regulation of gene expression, and responses to stress. This E3 ubiquitin ligase is involved in modulating protein interactions and stability, thus influencing critical cellular pathways that can impact cell survival and proliferation. Aberrant regulation of RNF138 has been implicated in several diseases, including cancer, where it may contribute to tumorigenesis by affecting the degradation of tumor suppressors or other regulatory proteins. Given its multifaceted functions, the study of recombinant RNF138 protein is crucial for elucidating its biochemical properties and interactions, as well as its overall biological significance. Research on RNF138 may provide insights into new therapeutic targets or strategies, particularly in the context of disorders linked to protein misfolding and cellular stress responses. As such, the preparation and characterization of RNF138 as a recombinant protein can facilitate deeper investigations into its mechanisms of action, potentially leading to novel applications in biotechnology and medicine.
