Analytical Data
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基因名
CDC14A
- Application
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别名
CDC14A; Dual specificity Protein phosphatase CDC14A; EC 3.1.3.16; EC 3.1.3.48; CDC14 cell division cycle 14 homolog A
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UNH5
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表达区间
1-594aa
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氨基酸序列
MAAESGELIG ACEFMKDRLY FATLRNRPKS TVNTHYFSID EELVYENFYA DFGPLNLAMV YRYCCKLNKK LKSYSLSRKK IVHYTCFDQR KRANAAFLIG AYAVIYLKKT PEEAYRALLS GSNPPYLPFR DASFGNCTYN LTILDCLQGI RKGLQHGFFD FETFDVDEYE HYERVENGDF NWIVPGKFLA FSGPHPKSKI ENGYPLHAPE AYFPYFKKHN VTAVVRLNKK IYEAKRFTDA GFEHYDLFFI DGSTPSDNIV RRFLNICENT EGAIAVHCKA GLGRTGTLIA CYVMKHYRFT HAEIIAWIRI CRPGSIIGPQ QHFLEEKQAS LWVQGDIFRS KLKNRPSSEG SINKILSGLD DMSIGGNLSK TQNMERFGED NLEDDDVEMK NGITQGDKLR ALKSQRQPRT SPSCAFRSDD TKGHPRAVSQ PFRLSSSLQG SAVTLKTSKM ALSPSATAKR INRTSLSSGA TVRSFSINSR LASSLGNLNA ATDDPENKKT SSSSKAGFTA SPFTNLLNGS SQPTTRNYPE LNNNQYNRSS NSNGGNLNSP PGPHSAKTEE HTTILRPSYT GLSSSSARFL SRSIPSLQSE YVHY
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分子量
90.97 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDC14A, a member of the CDC14 phosphatase family, plays a crucial role in cell cycle regulation and is implicated in various cellular processes such as mitotic exit, DNA repair, and maintenance of genomic stability. Initially discovered in yeast, CDC14A has been shown to dephosphorylate key substrates, facilitating the transition from mitosis to interphase. In humans, CDC14A exhibits significant expression in several tissues, suggesting diverse functional roles. Recent research has highlighted its involvement in cancer biology, with alterations in CDC14A expression linked to tumorigenesis and poor prognosis in various cancers. The study of CDC14A recombinant protein aims to elucidate its biochemical properties and interactions with other cellular components, providing insights into its regulatory mechanisms. Understanding CDC14A's functions at the molecular level could pave the way for new therapeutic strategies targeting cell cycle dysregulation in cancer. Moreover, generating recombinant CDC14A protein enables the development of specific inhibitors or modulators that could be employed in research and potential clinical applications. Overall, the investigation of CDC14A not only enhances our understanding of fundamental cellular processes but also holds promise for advancements in cancer treatment and other diseases associated with cell cycle abnormalities.
