Analytical Data
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基因名
L1CAM
- Application
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别名
L1CAM；CAML1；MIC5；Neural cell adhesion molecule L1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P32004-3
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表达区间
20-1115aa
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氨基酸序列
IQIPEELMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGV HFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAM SHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNS KILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEP IDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTI KWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHA YYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVE ELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL PAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERF FPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP RSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDG RLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLH LLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTS TTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGE GNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLV VSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEIL NSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVP ANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEAL HLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPE LRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNIS ATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSS YTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATELEHH HHHH
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分子量
124 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
L1CAM (L1 Cell Adhesion Molecule) is a transmembrane protein that plays a crucial role in neural development, cell adhesion, and cellular signaling. Its involvement in processes such as neuronal migration, axon guidance, and synaptic integrity has made it a significant focus of neurological research. Mutations and dysregulation of L1CAM are linked to various neurodevelopmental disorders, including X-linked hydrocephalus and intellectual disabilities, making it a potential target for therapeutic intervention. The study of L1CAM recombinant proteins is essential for understanding its structural and functional properties, which can reveal insights into its mechanism of action. Researchers utilize recombinant techniques to produce L1CAM in a controlled environment, allowing for the analysis of its interactions with other proteins and its role in cell signaling pathways. Furthermore, the recombinant form can be employed in cellular assays to evaluate its effects on neuronal cell behavior, providing valuable information that could inform the development of novel treatments for diseases associated with L1CAM dysfunction. As such, research into L1CAM recombinant proteins paves the way for advancements in our understanding of neurodevelopmental processes and the potential for targeted therapies in related disorders.
