Analytical Data
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基因名
S100PBP
- Application
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别名
S100P-binding protein; S100P-binding protein Riken; S100pbp; S100PBPR; S1PBP_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96BU1
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表达区间
1-408 aa
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氨基酸序列
MMCSRVPSEQ SSGTSLLPKD GAPFSWDSLD EDGLDDSLLE LSEGEEDDGD VNYTEEEIDA LLKEDDPSYE QSSGEDDGGH VEKGERGSQI LLDTPREKNS SYSLGPVAET PDLFKLPQLS TSSGHGPAHT KPLNRRSVLE KNLIKVTVAP FNPTVCDALL DKDETDSSKD TEKLSSLGEE MREDGLSPNE SKLCTESEGI SPNNSAWNGP QLSSSNNNFQ QTVSDKNMPD SENPTSVFSR ISDHSETPNM ELSCRNGGSH KSSCEMRSLV VSTSSNKQDV LNKDSGKMKG HERRLGKVIP VLQTKTRTNV PTFSQSNLEQ QKQLYLRSVI AHIEDPEDTN QGISGELCAL MDQVHHMQHS KWQHPSDLTT RNYARRQKHL QRYSLTQWVD RNMRSHHRFQ RLPDFSYS
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分子量
45.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
S100PBP (S100 calcium-binding protein P-binding protein) is an intriguing member of the S100 protein family, known for its role in various cellular processes, including cell proliferation, differentiation, and apoptosis. The S100 proteins are characterized by the presence of two EF-hand motifs that enable calcium binding, which can modulate their function in a calcium-dependent manner. S100PBP, specifically, has garnered attention due to its involvement in cancer biology, particularly in breast cancer and other malignancies, where it is implicated in tumor progression and metastasis. Understanding the mechanisms underlying S100PBP's actions in cancer cells may reveal novel therapeutic targets. Recent studies suggest that S100PBP interacts with various cellular partners, influencing signal transduction pathways and gene expression. The exploration of S100PBP as a potential biomarker for cancer prognosis further underscores its significance in oncology research. Additionally, the development of recombinant S100PBP allows researchers to study its structural properties and functional dynamics in vitro, providing insights into its role in cellular signaling and pathology. As research continues, elucidating the precise mechanisms of S100PBP in health and disease will be crucial for developing effective interventions and understanding its broader implications in human health.
