Analytical Data
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Gene name
CENTD3
- Application
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Alternative Names
ARAP3; CENTD3; Arf-GAP with Rho-GAP domain; ANK repeat and PH domain-containing Protein 3; Centaurin-delta-3; Cnt-d3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WWN8
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Expression Region
49-74aa
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AA Sequence
VEPPSSLPIRPCGDYTTGGPCPCSFQ
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Molecular Weight
28.6 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CENTD3, a member of the centromere protein family, has garnered attention in recent years due to its critical role in the cell cycle and chromosomal stability. Research indicates that CENTD3 is involved in the assembly of the centromere, facilitating proper kinetochore function during mitosis and meiosis. Disruptions in its expression or function can lead to aneuploidy and are implicated in various diseases, including cancer. Given the increasing awareness of the importance of centromere proteins in maintaining genomic integrity, scientists have focused on studying the structure and function of CENTD3, particularly through recombinant protein techniques. By producing and characterizing CENTD3 in vitro, researchers aim to elucidate its biochemical properties, interactions with other centromeric proteins, and contributions to chromosomal dynamics. Understanding CENTD3's mechanisms at the molecular level not only provides insights into fundamental cellular processes but also holds potential implications for therapeutic strategies targeting conditions arising from chromosomal instability.
