Analytical Data
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基因名
CTSC
- Application
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别名
CTSC；PRSSL1；Serine protease 57
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P53634-1
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表达区间
1-463aa
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氨基酸序列
MGAGPSLLLA ALLLLLSGDG AVRCDTPANC TYLDLLGTWV FQVGSSGSQR DVNCSVMGPQ EKKVVVYLQK LDTAYDDLGN SGHFTIIYNQ GFEIVLNDYK WFAFFKYKEE GSKVTTYCNE TMTGWVHDVL GRNWACFTGK KVGTASENVY VNIAHLKNSQ EKYSNRLYKY DHNFVKAINA IQKSWTATTY MEYETLTLGD MIRRSGGHSR KIPRPKPAPL TAEIQQKILH LPTSWDWRNV HGINFVSPVR NQASCGSCYS FASMGMLEAR IRILTNNSQT PILSPQEVVS CSQYAQGCEG GFPYLIAGKY AQDFGLVEEA CFPYTGTDSP CKMKEDCFRY YSSEYHYVGG FYGGCNEALM KLELVHHGPM AVAFEVYDDF LHYKKGIYHH TGLRDPFNPF ELTNHAVLLV GYGTDSASGM DYWIVKNSWG TGWGENGYFR IRRGTDECAI ESIAVAATPI PKL
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分子量
51 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CTSC, or Cathepsin C, is a vital enzyme belonging to the cysteine protease family and plays a crucial role in the processing and activation of several other proteases within immune and inflammatory pathways. Its significance in various physiological and pathological conditions has driven extensive research into its structure and function. Alterations in CTSC activity are linked to immunological disorders, including deficiency states and autoimmune diseases. The study of CTSC recombinant proteins has garnered considerable attention due to their potential therapeutic applications, including enzyme replacement therapies and the development of novel inhibitors to modulate immune responses. Additionally, a deeper understanding of CTSC's functional mechanisms can provide insights into its role in diseases such as cystic fibrosis and chronic obstructive pulmonary disease. Researchers aim to elucidate the enzyme's structure-function relationships through the production and characterization of CTSC recombinant proteins, which are essential for studying its catalytic activity and interactions with substrates and inhibitors. This research is crucial for developing targeted therapies that can effectively manipulate CTSC activity, offering promising avenues for treating conditions linked to disrupted proteolytic processing and inflammatory responses.
