Analytical Data
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基因名
tetM
- Application
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别名
tetM；tet；Tetracycline resistance Protein TetM
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种属
E.coli
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q53770
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表达区间
1-242aa
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氨基酸序列
MKIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDFVQAQTRILFHALRKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVELYPNMCVTNFTESEQWDTVIEGNDDLLEKYMSGKSLEALELEQEESIRFQNCSLFPLYHGSAKSNIGIDNLIEVITNKFYSST
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分子量
32.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TetM is a crucial protein involved in antibiotic resistance, specifically conferring resistance to tetracycline antibiotics in bacteria. This protein is classified as a ribosome protection protein, which enables bacteria to evade the inhibitory effects of tetracyclines by displacing the antibiotic from its binding site on the ribosome. The prevalence of tetM among various bacterial species, especially in pathogenic strains, has become a significant concern in public health due to the rising rates of antibiotic resistance. Researchers have focused on studying the molecular mechanisms of tetM to understand its structure and function better, which may provide insights into the development of novel antimicrobial strategies. Additionally, the transfer of tetM genes among bacteria highlights the urgent need for surveillance and effective measures to combat the spread of antibiotic resistance. Investigating the recombinant tetM protein can offer opportunities to identify potential drug targets and devise new therapeutic approaches to tackle infections caused by tetracycline-resistant bacteria, ultimately contributing to improved treatment regimens and health outcomes.
