Analytical Data
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基因名
TLK2
- Application
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别名
TLK2；Serine/threonine-Protein kinase tousled-like 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86UE8
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表达区间
1-772aa
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氨基酸序列
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN
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分子量
87kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TLK2 (Tousled-like kinase 2) is a serine/threonine kinase that plays a crucial role in DNA damage response and cell proliferation. Its expression is associated with several cellular processes, including chromatin remodeling, repair of DNA double-strand breaks, and regulation of the cell cycle. Dysregulation of TLK2 has been linked to various cancers, underscoring its potential as a biomarker for tumor diagnosis and a therapeutic target. Recent studies have focused on the recombinant expression of TLK2 to elucidate its functional mechanisms and interactions within cellular pathways. Recombinant TLK2 protein provides a valuable tool for understanding its enzymatic activity, substrate specificity, and role in oncogenic signaling. By investigating the interactions of TLK2 with other proteins involved in the DNA damage response, researchers aim to develop novel therapeutic strategies that can enhance DNA repair mechanisms in cancer cells or inhibit TLK2 activity in oncogenic contexts. These studies not only aim to characterize TLK2’s role in cell biology but also provide insights into its potential implications in cancer treatment, making it a focal point for ongoing cancer research and drug development initiatives. The production of recombinant TLK2 in various expression systems enables high-throughput screening and functional assays, which are essential for advancing our understanding of its biological significance and therapeutic potential.
