Analytical Data
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基因名
COPS3
- Application
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别名
Constitutive photomorphogenic homolog subunit 3; COP 9 (constitutive photomorphogenic) subunit 3; COP 9 complex homolog subunit 3; COP 9 complex S3; COP 9 complex subunit 3; COP 9 constitutive photomorphogenic homolog subunit 3; COP 9 homolog; COP 9 signalosome complex subunit 3; COP 9 signalosome subunit 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UNS2
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表达区间
2-423aa
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氨基酸序列
Constitutive photomorphogenic homolog subunit 3; COP 9 (constitutive photomorphogenic) subunit 3; COP 9 complex homolog subunit 3; COP 9 complex S3; COP 9 complex subunit 3; COP 9 constitutive photomorphogenic homolog subunit 3; COP 9 homolog; COP 9 signalosome complex subunit 3; COP 9 signalosome subunit 3; COP 9 subunit 3
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分子量
47.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COPS3, a component of the COP9 signalosome, plays a crucial role in various cellular processes, including protein degradation, signal transduction, and cell cycle regulation. The COP9 signalosome is a multiprotein complex that functions similarly to the proteasome, modulating the stability and activity of various proteins by regulating ubiquitination. COPS3, in particular, is implicated in the degradation of oncoproteins and has been linked to tumorigenesis, making it a potential target for cancer therapy. Recent studies have highlighted its involvement in pathways that govern the cellular response to stress, apoptosis, and inflammation, which further emphasizes its importance in maintaining cellular homeostasis. However, the exact mechanisms by which COPS3 exerts its functions remain to be fully elucidated. Research into the recombinant expression of COPS3 has gained momentum, as producing this protein in a purified form is essential for biochemical and structural studies to uncover its roles and interactions. Understanding the functional dynamics of COPS3 could potentially lead to novel therapeutic strategies, particularly against cancers where its regulatory functions are disrupted. The ongoing exploration of COPS3's biochemical properties and its interactions with other signaling molecules will contribute significantly to our understanding of cellular regulation and the development of targeted interventions in disease contexts.
