Analytical Data
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基因名
OAS2
- Application
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别名
OAS2；2'-5'-oligoadenylate synthase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P29728-2
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表达区间
1-687aa
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氨基酸序列
MGNGESQLSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEPEQ FPLVQGVAIGGSYGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDK TGDKLKFCLFTKWLKNNFEIQKSLDGFTIQVFTKNQRISFEVLAAFNALS LNDNPSPWIYRELKRSLDKTNASPGEFAVCFTELQQKFFDNRPGKLKDLI LLIKHWHQQCQKKIKDLPSLSPYALELLTVYAWEQGCRKDNFDIAEGVRT VLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQSARPVILDPVDPTNN VSGDKICWQWLKKEAQTWLTSPNLDNELPAPSWNVLPAPLFTTPGHLLDK FIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAKIQIVRGGSTAKG TALKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEEL EVSFEPPKWKAPRVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSP EVYAGLIDLYKSSDLPGGEFSTCFTVLQRNFIRSRPTKLKDLIRLVKHWY KECERKLKPKGSLPPKYALELLTIYAWEQGSGVPDFDTAEGFRTVLELVT QYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEPTGDVGGGDR WCWHLLAKEAKEWLSSPCFKDGTGNPIPPWKVPVKVI
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分子量
105 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of OAS2 recombinant protein is rooted in its critical role in the innate immune response against viral infections. Oligoadenylate synthase 2 (OAS2) is an enzyme that is part of the OAS family, activated by double-stranded RNA, a common byproduct of viral replication. Upon activation, OAS2 synthesizes 2',5'-linked oligoadenylates, leading to the activation of RNase L, which subsequently degrades viral RNA, thus inhibiting viral replication. There is growing interest in OAS2 due to its potential therapeutic applications in treating viral infections and its involvement in various pathologies, including autoimmune diseases and cancer. By engineering recombinant OAS2 proteins, researchers aim to better understand its structure-function relationships, optimize its antiviral properties, and explore its efficacy in different therapeutic contexts. Recent advancements in molecular biology techniques allow for the production and purification of active OAS2, facilitating detailed biochemical and functional studies. Investigating OAS2 not only enriches our fundamental understanding of viral pathogenesis and host defense mechanisms but also paves the way for novel antiviral strategies and diagnostics. As researchers continue to explore the intricate dynamics of OAS2 and its interactions within the immune system, it holds promise for enhancing our ability to combat a range of viral diseases effectively.
