Analytical Data
-
Gene name
CYP26C1
- Application
-
Alternative Names
CP26C_HUMAN; cyp26b1l; CYP26C1; cyp26d1; Cytochrome P450 26C1; Cytochrome P450 family 26 subfamily C polypeptide 1; Cytochrome P450; subfamily XXVIC polypeptide 1
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q6V0L0
-
Expression Region
1-522aa
-
AA Sequence
MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDASKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRARDQLHRHLEGAISEKLHEDKAAEPGDALDLIIHSARELGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWELATPAFPAMQTVPIVHPVDGLRLFFHPLTPSVAGNGLCL
-
Molecular Weight
57.1 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CYP26C1, a member of the cytochrome P450 enzyme family, is primarily involved in the metabolism of retinoic acid, a derivative of vitamin A crucial for various physiological processes including embryonic development, cellular differentiation, and tissue homeostasis. Its role in retinoic acid catabolism makes it vital for regulating retinoic acid levels in cells, thereby influencing gene expression and signaling pathways. Dysregulation of CYP26C1 has been linked to developmental disorders and certain cancers, underscoring the enzyme's importance in maintaining proper retinoid balance. Research into the recombinant protein of CYP26C1 aims to elucidate its enzymatic mechanisms, substrate specificity, and potential influence on retinoic acid signaling. This understanding can lead to innovative therapeutic strategies targeting diseases associated with retinoic acid dysregulation, enhancing our knowledge of retinoid biology as well as providing insight into the development of new drugs that modulate CYP26C1 activity for clinical applications.
