Analytical Data
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Gene name
SLC6A7
- Application
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Alternative Names
solute carrier family 6 (neurotransmitter transporter; L-proline); member 7; brain-specific L-proline transporter; L-proline transporter; brain-specific; PROT; SC6A7_HUMAN; Slc6a7; Sodium-dependent proline transporter; solute carrier family 6 (neurotransmitter transporter); member 7; Solute carrier family 6 member 7
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99884
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Expression Region
1-636 aa
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AA Sequence
MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM
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Molecular Weight
97.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC6A7, also known as the sodium-dependent neutral amino acid transporter, plays a crucial role in neurotransmitter and amino acid transport across the cell membrane. This protein is particularly important in the central nervous system, where it regulates the levels of neurotransmitters such as glutamate and glycine, influencing synaptic plasticity and neurotransmission. Dysregulation of SLC6A7 has been implicated in various neurological disorders, including schizophrenia and autism spectrum disorders, making it a significant target for pharmacological research. The study of recombinant SLC6A7 protein allows for a better understanding of its functional properties and transport mechanisms. By expressing and purifying this protein in a heterologous system, researchers can examine its structure, transport kinetics, and substrate specificity. This has important implications for the development of new therapeutics aimed at modulating the function of SLC6A7 and addressing the associated pathophysiological conditions. Furthermore, characterizing SLC6A7 in vitro can help identify potential inhibitors or modulators that could serve as drugs for related disorders, paving the way for novel treatment approaches. Overall, the research on recombinant SLC6A7 is vital to uncovering the molecular underpinnings of its role in health and disease, facilitating advancements in neuroscience and therapeutic strategies.
